ISO 45001-2018 (Occupational Health and Safety Standard) ISO 45001 is the world’s international standard for occupational health and safety, issued to protect employees and visitors from work-related accidents and diseases. For organizations that are serious about improving employee safety, reducing workplace risks and creating better, safer working conditions, there’s ISO 45001. ISO 45001:2018 is the replacement to OHSAS 18001 and is the international ISO standard for Occupational Health and Safety Management Systems (OHSMS).